Volume 7 Supplement 2

The Third International Symposium on the Molecular Biology of Breast Cancer

Meeting abstracts

Affymetrix, Agilent Technologies, Applied Biosystems, AstraZeneca, Novartis Oncology, Pfizer, Roche Diagnostics (Main Sponsors).

The Third International Symposium on the Molecular Biology of Breast Cancer.

Molde, Norway22-26 June 2005

Page 1 of 4

The challenges in translating present knowledge of the molecular biology of breast cancer into clinical use

Authors: N Davidson

Citation: Breast Cancer Research 2005 7(Suppl 2):S.01

Content type: Oral Presentation Published on: 17 June 2005
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Stromal and epithelial TGF-β signaling in mammary tumorigenesis

Authors: HL Moses, N Cheng, A Chytil, AE Gorska, M Aakre, E Forrester, EG Neilson and NA Bhowmick

Citation: Breast Cancer Research 2005 7(Suppl 2):S.02

Content type: Oral Presentation Published on: 17 June 2005
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Genomic analysis of human breast cancer in families and populations

Authors: M-C King

Citation: Breast Cancer Research 2005 7(Suppl 2):S.03

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Abstract withdrawn

Authors:

Citation: Breast Cancer Research 2005 7(Suppl 2):S.04

Content type: Oral Presentation Published on: 17 June 2005
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ATM mutations associated with breast cancer

Authors: RA Gatti and P Concannon

Citation: Breast Cancer Research 2005 7(Suppl 2):S.05

Content type: Oral Presentation Published on: 17 June 2005
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DNA damage response pathways in cancer causation and treatment

Authors: MB Kastan, R Kitagawa and CJ Bakkenist

Citation: Breast Cancer Research 2005 7(Suppl 2):S.06

Content type: Oral Presentation Published on: 17 June 2005
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SNPS in putative regulatory loci controlling gene expression in cancer

Authors: VN Kristensen

Citation: Breast Cancer Research 2005 7(Suppl 2):S.07

Content type: Oral Presentation Published on: 17 June 2005
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Potential mechanisms whereby estrogens induce breast cancer in women

Authors: RJ Santen, W Yue and J-P Wang

Citation: Breast Cancer Research 2005 7(Suppl 2):S.08

Content type: Oral Presentation Published on: 17 June 2005
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The future of breast cancer prevention

Authors: A Howell, A Sims, M Harvie, KR Ong, G Evans and R Clarke

Citation: Breast Cancer Research 2005 7(Suppl 2):S.09

Content type: Oral Presentation Published on: 17 June 2005
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Targeting estrogen to kill ER-positive and ER-negative breast cancer

Authors: VC Jordan

Citation: Breast Cancer Research 2005 7(Suppl 2):S.10

Content type: Oral Presentation Published on: 17 June 2005
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ERβ in normal and malignant breast

Authors: J-Å Gustafsson, G Cheng and M Warner

Citation: Breast Cancer Research 2005 7(Suppl 2):S.11

Content type: Oral Presentation Published on: 17 June 2005
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Molecular approaches to understanding pregnancy-induced protection against breast cancer

Authors: CM Blakely, SE Moody, A Stoddard, E Tombler, C Liu and LA Chodosh

Citation: Breast Cancer Research 2005 7(Suppl 2):S.12

Content type: Oral Presentation Published on: 17 June 2005
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Predicting response/resistance to endocrine therapy for breast cancer

Authors: WR Miller, TJ Anderson, D Evans, A Krause and JM Dixon

Citation: Breast Cancer Research 2005 7(Suppl 2):S.13

Content type: Oral Presentation Published on: 17 June 2005
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Genetic and epigenetic changes in early carcinogenesis

Authors: TD Tlsty

Citation: Breast Cancer Research 2005 7(Suppl 2):S.14

Content type: Oral Presentation Published on: 17 June 2005
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A breast cancer progression model: the importance of three-dimensional tissue architecture and metalloproteinases

Authors: MJ Bissell, C Myers, G Lee, E Lee, A Rizki, S Mian, J Gray and D Radisky

Citation: Breast Cancer Research 2005 7(Suppl 2):S.15

Content type: Oral Presentation Published on: 17 June 2005
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Genomic and transcriptional events associated with poor clinical responses to conventional therapies

Authors: K Chin, S Devries, J Fridlyand, P Spellman, W-L Kuo, A Lapuk, R Neve, T Tokuyasu, C Kingsley, S Dairkee, K Chew, A Jain, BM Ljung, L Esserman, F Waldman and JW Gray

Citation: Breast Cancer Research 2005 7(Suppl 2):S.16

Content type: Oral Presentation Published on: 17 June 2005
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The role of the tumor microenvironment in breast cancer progression

Authors: H Min, J Yao, M Allinen, L Cai and K Polyak

Citation: Breast Cancer Research 2005 7(Suppl 2):S.17

Content type: Oral Presentation Published on: 17 June 2005
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Biological features and xenograft models of a very early human premalignant breast lesion

Authors: S Lee, Y Wu, SK Mohsin, D Medina and DC Allred

Citation: Breast Cancer Research 2005 7(Suppl 2):S.18

Content type: Oral Presentation Published on: 17 June 2005
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Regulation of epithelial cell polarity during carcinogenesis

Authors: SK Muthuswamy

Citation: Breast Cancer Research 2005 7(Suppl 2):S.19

Content type: Oral Presentation Published on: 17 June 2005
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Expression profiling of peripheral blood cells for early detection

Authors: A-L Børresen-Dale and P Sharma

Citation: Breast Cancer Research 2005 7(Suppl 2):S.20

Content type: Oral Presentation Published on: 17 June 2005
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Stem cells in human breast development and cancer

Authors: M Wicha, G Dontu, S Liu and I Mantle

Citation: Breast Cancer Research 2005 7(Suppl 2):S.21

Content type: Oral Presentation Published on: 17 June 2005
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Molecular distinctions among ERBB2-overexpressing breast cancers

Authors: SS Jeffrey

Citation: Breast Cancer Research 2005 7(Suppl 2):S.22

Content type: Oral Presentation Published on: 17 June 2005
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Insulin-like growth factor regulation of mammary gland development and tumorigenesis

Authors: AV Lee

Citation: Breast Cancer Research 2005 7(Suppl 2):S.23

Content type: Oral Presentation Published on: 17 June 2005
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Targeting the cell cycle for prognosis and therapy of breast cancer

Authors: K Keyomarsi and S Akli

Citation: Breast Cancer Research 2005 7(Suppl 2):S.24

Content type: Oral Presentation Published on: 17 June 2005
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Apoptotic chemotherapies

Authors: AB Pardee, PV Reddy, DK Biswas and CJ Li

Citation: Breast Cancer Research 2005 7(Suppl 2):S.25

Content type: Oral Presentation Published on: 17 June 2005
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High-resolution representational oligonucleotide microarray analysis and fluorescence in situ hybridization analysis of aneuploid and diploid breast tumors

Authors: J Hicks, V Grubor, N Navin, P Lundin, S Månér, T Hägerström, L Skoog, M Wigler and A Zetterberg

Citation: Breast Cancer Research 2005 7(Suppl 2):S.26

Content type: Oral Presentation Published on: 17 June 2005
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Tailored therapies based upon tumor subtype biology

Authors: CM Perou

Citation: Breast Cancer Research 2005 7(Suppl 2):S.27

Content type: Oral Presentation Published on: 17 June 2005
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Expression profiling as a prognostic and predictive factor in breast cancer

Authors: LJ van 't Veer

Citation: Breast Cancer Research 2005 7(Suppl 2):S.28

Content type: Oral Presentation Published on: 17 June 2005
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Genomic profiling of breast cancer

Authors: Å Borg

Citation: Breast Cancer Research 2005 7(Suppl 2):S.29

Content type: Oral Presentation Published on: 17 June 2005
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A single nucleotide polymorphism in the HDM-2 gene regulates the p53 apoptotic response and influences the age of onset of cancers in humans: the SNP 309 HDM-2 polymorphism

Authors: GL Bond and AJ Levine

Citation: Breast Cancer Research 2005 7(Suppl 2):S.30

Content type: Oral Presentation Published on: 17 June 2005
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Evading p53 action during tumor development and therapy

Authors: SW Lowe

Citation: Breast Cancer Research 2005 7(Suppl 2):S.31

Content type: Oral Presentation Published on: 17 June 2005
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TP53 and additional pathways in therapy resistance

Authors: PE Lønning

Citation: Breast Cancer Research 2005 7(Suppl 2):S.32

Content type: Oral Presentation Published on: 17 June 2005
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Dynamic imaging of plasticity and escape in tumor cell invasion

Authors: P Friedl

Citation: Breast Cancer Research 2005 7(Suppl 2):S.33

Content type: Oral Presentation Published on: 17 June 2005
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Role of HER2 in local relapse and metastasis

Authors: S Ménard

Citation: Breast Cancer Research 2005 7(Suppl 2):S.34

Content type: Oral Presentation Published on: 17 June 2005
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Molecular profiling of early breast cancer in relation to detection of micrometastases and outcome

Authors: B Naume and T Sørlie

Citation: Breast Cancer Research 2005 7(Suppl 2):S.35

Content type: Oral Presentation Published on: 17 June 2005
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Update on HER2-directed therapy

Authors: D Slamon

Citation: Breast Cancer Research 2005 7(Suppl 2):S.36

Content type: Oral Presentation Published on: 17 June 2005
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Targeting new therapies in combination with hormonal therapies for ER-positive breast cancer

Authors: M Dowsett

Citation: Breast Cancer Research 2005 7(Suppl 2):S.37

Content type: Oral Presentation Published on: 17 June 2005
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Development of CDK inhibitors as cancer therapeutics

Authors: D Lane

Citation: Breast Cancer Research 2005 7(Suppl 2):S.38

Content type: Oral Presentation Published on: 17 June 2005
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Genes, genomes, and cancer

Authors: D Botstein

Citation: Breast Cancer Research 2005 7(Suppl 2):S.39

Content type: Oral Presentation Published on: 17 June 2005
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The search for low-penetrance breast cancer genes

Authors: BAJ Ponder, A Cebrian, AM Dunning, DF Easton, F Lesueur, C Luccarini and PDP Pharoah

Citation: Breast Cancer Research 2005 7(Suppl 2):S.40

Content type: Oral Presentation Published on: 17 June 2005
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Functional genomic approaches to breast cancer

Authors: R Bernards

Citation: Breast Cancer Research 2005 7(Suppl 2):S.41

Content type: Oral Presentation Published on: 17 June 2005
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Proteomic approaches to early detection of breast cancer

Authors: JE Celis, P Gromov, JMA Moreira, T Cabezón, E Friis, F Rank and I Gromova

Citation: Breast Cancer Research 2005 7(Suppl 2):S.42

Content type: Oral Presentation Published on: 17 June 2005
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Dissection of molecular pathways of cancer by high-throughput biochip technologies and RNA interference

Authors: O Kallioniemi

Citation: Breast Cancer Research 2005 7(Suppl 2):S.43

Content type: Oral Presentation Published on: 17 June 2005
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Envisioning new targets and new approaches for molecular-based cancer therapeutics

Authors: JA Tainer

Citation: Breast Cancer Research 2005 7(Suppl 2):S.44

Content type: Oral Presentation Published on: 17 June 2005
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Cigarette smoking and breast cancer risk among non-drinking women

Authors: IT Gram, T Braaten, HO Adami, E Lund and E Weiderpass

Citation: Breast Cancer Research 2005 7(Suppl 2):P1.01

Content type: Poster Presentation Published on: 17 June 2005
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Mutation screening of BRCA1, BRCA2 and CHEK2*1100delC in Slovak HBOC families

Authors: S Cierniková, M Tomka, M Kovac, V Stevurkova, V Bella, J Novotny and V Zajac

Citation: Breast Cancer Research 2005 7(Suppl 2):P1.02

Content type: Poster Presentation Published on: 17 June 2005
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Identification of novel sequence alterations and the functional analysis of the BRCA1 promoter/5'-UTR in families from Upper Silesia, Poland

Authors: J Pamuła, M Krześniak, H Zientek, WP Pękala, M Rusin and E Grzybowska

Citation: Breast Cancer Research 2005 7(Suppl 2):P1.03

Content type: Poster Presentation Published on: 17 June 2005
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High prevalence of a BRCA1 gene founder mutation, 5083del19, in unselected breast–ovarian cancer patients from Southern Italy: genotype–phenotype correlations

Authors: F Baudi, AM Lavecchia, B Quaresima, MC Faniello, L De Paola, W D'Amico, F Fabiani, G Cuda, FS Costanzo and S Venuta

Citation: Breast Cancer Research 2005 7(Suppl 2):P1.04

Content type: Poster Presentation Published on: 17 June 2005
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Screening for germline rearrangements in BRCA1 and BRCA2in Norwegian families with breast or breast/ovarian cancer

Authors: M Van Ghelue, M Ingebrigtsen, HMF Riise Stensland, L Mæhle, J Apold, P Møller, V Marton and C Jonsrud

Citation: Breast Cancer Research 2005 7(Suppl 2):P1.05

Content type: Poster Presentation Published on: 17 June 2005
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Hereditary breast cancer – a spectrum of pathogenic mutations and unknown variants of BRCA1 and BRCA2 genes in the Czech Republic: efficiency of testing and clinical follow-up

Authors: L Foretova, M Lukesova, P Vasickova, M Navratilova, H Pavlu, J Kuklova, V Urbankova, D Hanouskova, B Dvorackova and E Machackova

Citation: Breast Cancer Research 2005 7(Suppl 2):P1.06

Content type: Poster Presentation Published on: 17 June 2005
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The Third International Symposium on the Molecular Biology of Breast Cancer

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