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Table 4 Associations between, clinical depression, antidepressant use, and breast cancer risk; stratified by family history

From: Depression, antidepressant use, and breast cancer incidence in the Sister Study cohort

 

Clinical Depression

Antidepressant Use

 

1 1st deg Relative

 > 1 1st deg Relative

1 1st deg Relative

 > 1 1st deg Relative

 

Exposed/Non-Exposed Cases

HR (95% CI)

Exposed/Non-Exposed Cases

HR (95% CI)

Het

Exposed/Non-Exposed Cases

HR (95% CI)

Exposed/Non-Exposed Cases

HR (95% CI)

Het

Overalla

597/1925

1.00 (0.91, 1.10)

320/1057

0.95 (0.83, 1.07)

0.50

515/2007

0.96 (0.87, 1.06)

275/1102

0.86 (0.75, 0.98)

0.22

DCIS

112/404

0.92 (0.74, 1.14)

78/226

1.11 (0.86, 1.45)

0.28

96/420

0.88 (0.70, 1.10)

62/242

0.90 (0.67, 1.19)

0.93

Invasive

483/1518

1.02 (0.92, 1.14)

241/829

0.90 (0.78, 1.04)

0.18

417/1584

0.98 (0.88, 1.10)

213/857

0.85 (0.73, 0.99)

0.18

ER positiveb

364/1116

1.05 (0.93, 1.18)

185/627

0.91 (0.77, 1.07)

0.20

325/1155

1.04 (0.92, 1.18)

165/647

0.87 (0.73, 1.03)

0.13

ER negativeb

54/196

0.86 (0.63, 1.17)

27/97

0.81 (0.53, 1.24)

0.86

47/203

0.84 (0.61, 1.17)

22/102

0.68 (0.42, 1.08)

0.50

Overall Premenopausal

83/322

0.97 (0.76, 1.24)

43/142

1.07 (0.75, 1.52)

0.68

81/324

1.09 (0.85, 1.39)

37/148

0.98 (0.67, 1.44)

0.64

Overall Postmenopausal

514/1603

1.01 (0.91, 1.12)

277/915

0.93 (0.81, 1.06)

0.38

434/1683

0.94 (0.84, 1.05)

238/954

0.84 (0.73, 0.97)

0.31

Invasive Premenopausal

65/253

0.95 (0.72, 1.24)

31/109

1.00 (0.66, 1.50)

0.82

64/254

1.08 (0.81, 1.42)

25/115

0.85 (0.53, 1.34)

0.38

Invasive Postmenopausal

418/1265

1.03 (0.92, 1.16)

210/720

0.89 (0.76, 1.03)

0.14

353/1330

0.96 (0.86, 1.09)

188/742

0.85 (0.72, 1.00)

0.31

  1. Abbreviations: DCIS ductal carcinoma in situ, ER estrogen receptor
  2. All models were adjusted for age, race/ethnicity, age at menarche, breastfeeding history, parity, menopausal status, any hormonal contraceptive use, hormone therapy type, oophorectomy status, BMI, physical activity level, smoking status, alcohol intake, mammogram in prior 2 years, alternative healthy eating index score, education level, annual household income per person, and age at first birth
  3. Clinical Depression models (excluding by menopausal status) also adjusted for interaction between BMI and menopausal status at baseline
  4. Reference group: For the clinical depression models (women without a clinical depression diagnosis); for the antidepressant use models (non-users of antidepressants)
  5. aIncludes Invasive and DCIS breast cancer
  6. bn = 23 were excluded due to unknown ER status
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Breast Cancer Research

ISSN: 1465-542X

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