Table 1 Characteristics of the Sister Study participants by Clinical Depression (n = 45,746)
From: Depression, antidepressant use, and breast cancer incidence in the Sister Study cohort
History of Depression (n = 9,410) | No History of Depression (n = 36,336) | |
|---|---|---|
Characteristic | ||
Age in years, mean (SD) | 55.1 (8.3) | 55.6 (9.1) |
Follow-up time in years, mean (SD) | 11.3 (3.3) | 11.8 (3.2) |
Race/Ethnicity, n (%) | ||
Non-Hispanic White | 8104 (86.1%) | 30,666 (84.4%) |
Non-Hispanic Black | 597 (6.3%) | 3117 (8.6%) |
Hispanic | 442 (4.7%) | 1617 (4.5%) |
Other | 267 (2.8%) | 936 (2.6%) |
Highest level of Education, n (%) | ||
High school/GED and lower | 1304 (13.9%) | 5564 (15.3%) |
Associates degree/some college | 3370 (35.8%) | 11,934 (32.8%) |
4-year degree or higher | 4736 (50.3%) | 18,838 (51.8%) |
Annual household income per person in dollars, mean (SD) | 40,052.7 (26,636.2) | 43,144.9 (27,086.9) |
First-degree family history of breast cancer, n (%) | ||
1 affected sister or half-sister | 6877 (73.1%) | 26,595 (73.2%) |
2 + affected 1 st degree relatives | 2533 (26.9%) | 9741 (26.8%) |
Age at menarche in years, mean (SD) | 12.6 (1.5) | 12.7 (1.5) |
Parity, n (%) | ||
Nulliparous | 1889 (20.1%) | 6494 (17.9%) |
1 birth | 1511 (16.1%) | 5130 (14.1%) |
2 births | 3435 (36.5%) | 13,461 (37%) |
3 + births | 2575 (27.4%) | 11,251 (31%) |
Age at first birth, n(%) | ||
Never had a term pregnancy | 1889 (20.1%) | 6494 (17.9%) |
< 20 | 1345 (14.3%) | 4635 (12.8%) |
20–29 | 4810 (51.1%) | 19,838 (54.6%) |
30–39 | 1297 (13.8%) | 5101 (14%) |
40 + | 69 (0.7%) | 268 (0.7%) |
Breast feeding history, n (%) | ||
None/< 1 month | 4548 (48.3%) | 17,161 (47.2%) |
1 month—< 1 year | 2710 (28.8%) | 10,436 (28.7%) |
1- < 2 years | 1204 (12.8%) | 4937 (13.6%) |
> = 2 years | 948 (10.1%) | 3802 (10.5%) |
Menopausal status, n (%) | ||
Pre-menopausal | 2913 (31%) | 12,103 (33.3%) |
Post-menopausal | 6497 (69%) | 24,233 (66.7%) |
Ever used any hormonal contraceptive, n (%) | 8363 (88.9%) | 30,809 (84.8%) |
Horomone Therapy Use, n (%) | ||
None | 5020 (53.3%) | 21,340 (58.7%) |
Estrogen alone | 2134 (22.7%) | 6841 (18.8%) |
Estrogen + Progestin | 2256 (24%) | 8155 (22.4%) |
Had oophorectomy, n (%) | 2631 (28%) | 8415 (23.2%) |
BMI (kg/m2), mean (SD) | 28.9 (6.7) | 27.1 (5.8) |
Total physical activity in MET-hours/week, mean (SD) | 11.3 (15.7) | 15.2 (18.1) |
Smoking status, n (%) | ||
Never Smoked | 4759 (50.6%) | 21,002 (57.8%) |
Past Smoker | 3567 (37.9%) | 12,735 (35%) |
Current Smoker | 1084 (11.5%) | 2599 (7.2%) |
Alcohol drinking status, n (%) | ||
Never | 259 (2.8%) | 1415 (3.9%) |
Former | 1742 (18.5%) | 5064 (13.9%) |
Current | 7409 (78.7%) | 29,857 (82.2%) |
Had mammogram in the past 2 years, n (%) | 8937 (95%) | 34,695 (95.5%) |
AHEI score 2010, mean (SD) | 59 (11.9) | 60.3 (11.7) |
Antidepressant Use, n (%) | 6350 (67.5%) | 3593 (9.9%) |
Antidepressant Class, n (%) | ||
No AD | 3073 (32.7%) | 32,748 (90.1%) |
SSRI alone | 3304 (35.1%) | 1860 (5.1%) |
SNRI alone | 873 (9.3%) | 515 (1.4%) |
TCA alone | 222 (2.4%) | 560 (1.5%) |
Non-SSRI/SNRI/MAOI/TCA AD alone | 837 (8.9%) | 449 (1.2%) |
Other AD combinations | 1101 (11.7%) | 204 (0.6%) |