Fig. 1

CD105⁺ fibroblasts are more abundant in cultures from older women and women with BRCA1 mutations. A Flow cytometry measurement of CD105 proportion in fibroblasts from women ranging from 16 to 70 years of age (n = 20); simple linear regression plotted with 95% confidence intervals. B Flow cytometry measurement of CD105 proportion in fibroblasts from age-matched women with varying BRCA1 mutational status (AR n = 13, BRCA1^mut/+ n = 10); unpaired t test with Welch’s correction (P value = 0.026). C Population doublings of CD105⁺ and CD105^- fibroblasts from women with different BRCA1 mutational statuses in serial passage subculture, error bars represent standard deviation, two-way ANOVA (**** = P < 0.0001)