Table 2 Hazard ratios and 95% confidence intervals of candidate prognostic factors of the multivariable Cox proportional hazards models on overall survival of 421 breast cancer patients of the ISE cohort

Cancer-related Fatigue*

< 5 Years of Follow-Up

1.26 (0.56 to 2.84)

0.57

1.29 (0.57 to 2.90)

0.54

≥ 5 Years of Follow-Up

2.44 (1.12 to 5.32)

0.02

1.64 (0.97 to 2.77)

0.07

Tumour Size (T2–T4 vs. in Situ/T0/T1/TX)

3.02 (1.69 to 5.38)

< 0.005

1.99 (1.24 to 3.20)

< 0.005

Nodal Involvement (N1/N2 vs. N0/NX)

2.56 (1.41 to 4.65)

< 0.005

1.89 (1.14 to 3.14)

0.01

Grading

Grade 1

Reference

Grade 2

0.69 (0.32 to 1.49)

0.34

0.77 (0.42 to 1.40)

0.40

Grade 3

0.77 (0.31 to 1.94)

0.58

0.79 (0.38 to 1.65)

0.54

Hormone Receptor Positivity (ER/PR)

0.46 (0.19 to 1.11)

0.08

0.47 (0.24 to 0.95)

0.04

Age

1.05 (1.02 to 1.09)

< 0.005

1.09 (1.06 to 1.11)

< 0.005

Body Mass Index (kg/m²)

1.05 (0.99 to 1.12)

0.13

1.02 (0.96 to 1.07)

0.54