Biomechanical parameters quantified by MR elastography for predicting response to neoadjuvant chemotherapy and disease-free survival in breast cancer: a prospective longitudinal study

Table 4 Univariable and multivariable analyses of the associations of pretreatment clinicopathological characteristics and mechanical parameters for predicting disease-free survival

Predictor	Univariable Analysis				Multivariable Analysis
Predictor	Hazard ratio	95% confidence interval	^*P Value	β coefficient	Hazard ratio	95% confidence interval	^§P Value
Clinicopathological Characteristics
Age	1.02	0.97, 1.08	0.45
Menstruation status
Premenopausal	Reference
Postmenopausal	2.28	0.90, 5.81	0.08	0.98	2.67	0.91, 7.87	0.07
Position
Left	Reference
Right	1.21	0.53, 2.76	0.65
Location
Lower inner quadrant	1.00	0.18, 5.48	0.99
Lower outer quadrant	0.19	0.02, 1.57	0.12
Upper outer quadrant	0.89	0.30, 2.66	0.83
Upper inner quadrant	Reference
ER
Negative	Reference
Positive	0.43	0.19, 0.99	0.04	-2.01	0.13	0.05, 0.36	< 0.001
PR
Negative	Reference
Positive	0.47	0.17, 1.25	0.13
HER2
Negative	Reference
Positive	0.21	0.06, 0.72	0.01	-1.41	0.25	0.06, 0.94	0.04
Ki67
Negative	Reference
Positive	5.04	0.68, 37.36	0.11
Clinical stage
II	Reference
III	8.53	1.15, 63.34	0.03	2.41	11.07	1.37, 89.15	0.02
NAC response
non-pCR	Reference
pCR	0.26	0.06, 1.11	0.06	-1.12	0.33	0.06, 1.71	0.19
Mechanical Parameters
T1-c (m/sec)	0.27	0.80, 2.23	0.27
T1-φ (radian)	0.78	0.22, 2.70	0.69
T2-c (m/sec)	2.03	1.21, 3.42	0.008	-0.02	0.98	0.54, 1.78	0.94
T2-φ (radian)	3.03	0.65, 14.07	0.16
T3-c (m/sec)	1.74	1.00, 3.04	0.04	-0.07	0.93	0.49, 1.76	0.83
T3-φ (radian)	0.77	0.18, 3.28	0.73
T4-c (m/sec)	1.69	0.92, 3.11	0.08	0.03	1.03	0.45, 2.35	0.94
T4-φ (radian)	2.27	0.71, 7.23	0.17
Δc_T1−2(m/sec)	0.77	0.46, 1.28	0.31
Δφ_T1−2(radian)	0.25	0.10, 0.65	0.004	-1.39	0.25	0.07, 0.67	0.03
Δc_T1−3(m/sec)	0.86	0.54, 1.38	0.53
Δφ_T1−3(radian)	0.97	0.38, 2.47	0.94
Δc_T1−4(m/sec)	0.92	0.57, 1.49	0.73
Δφ_T1−4(radian)	0.43	0.17, 1.11	0.08	-0.39	0.68	0.17, 2.66	0.58

Note.—ER = estrogen receptor, PR = progesterone receptor, HER2 = human epidermal growth factor receptor-2, TNBC = triple negative breast cancer
^*The univariable cox regression analyses was used;
^§The multivariable cox regression analyses was used

ISSN: 1465-542X