Biomechanical parameters quantified by MR elastography for predicting response to neoadjuvant chemotherapy and disease-free survival in breast cancer: a prospective longitudinal study

Table 2 Univariable and multivariable analyses of the associations of pretreatment clinicopathological characteristics and Biomechanical parameters with pathologic complete response

Predictor	Univariable analysis			Multivariable analysis
Predictor	Odds ratio	95% CI	*P-value	β coefficient	Odds ratio	95% CI	§P-value
Clinicopathological characteristics
Age	1.06	0.79, 1.42	0.71
Menstruation status
Premenopausal	Reference
Postmenopausal	1.3	0.71, 2.76	0.39
Position
Left	Reference
Right	1.08	0.60, 1.93	0.80
Location
Lower inner quadrant	0.85	0.27, 2.70	0.78
Lower outer quadrant	1.44	0.69, 2.99	0.34
Upper outer quadrant	0.74	0.41, 1.39	0.32
Upper inner quadrant	Reference
ER status
Negative	Reference
Positive	0.25	0.14, 0.46	< 0.001	-0.35	0.70	0.21, 2.31	0.56
PR status
Negative	Reference
Positive	0.07	0.03, 0.22	< 0.001	-2.91	0.05	0.01, 0.34	0.002
HER2 status
Negative	Reference
Positive	4.89	2.62, 9.12	< 0.001	2.01	7.47	2.26, 24.71	0.001
Ki67 status
Negative	Reference
Positive	1.77	0.77, 4.06	0.18
cT stage
1	Reference
2	1.17	0.66, 2.01	0.59
3	2.08	1.00, 4.31	0.051
4	1.21	0.30, 4.82	0.79
cN stage
0	Reference
1	1.37	0.75, 2.52	0.31
2	0.62	0.34, 1.14	0.13
3	1.36	0.64, 2.89	0.43
Mechanical parameters
T1-c (m/sec)	0.83	0.61, 1.25	0.23
T1-φ (radian)	0.93	0.70, 1.25	0.64
T2-c (m/sec)	0.14	0.08, 0.25	< 0.001	-2.28	0.10	0.04, 0.29	< 0.001
T2-φ (radian)	0.17	0.10, 0.29	< 0.001	-2.20	0.11	0.04, 0.30	< 0.001
Δc_T1−2(m/sec)	1.90	1.37, 2.62	< 0.001	0.24	1.27	0.67, 2.42	0.47
Δφ_T1−2(radian)	2.49	1.72, 3.61	< 0.001	0.34	1.41	0.72, 2.76	0.32

Note.—ER = estrogen receptor, PR = progesterone receptor, HER2 = human epidermal growth factor receptor-2, TNBC = triple-negative breast cancer
*Univariable logistic regression analysis was used
§Multivariable logistic regression analysis was used

ISSN: 1465-542X