Fig. 3

Trajectories of biomechanical parameters derived from multifrequency MR elastography during neoadjuvant chemotherapy. Individual panels show changes in c (stiffness) and φ (viscosity) among patients in pCR (green) and non-pCR (red) groups. Time 1, before NAC; Time 2, after 2 cycles of NAC; Time 3, after 4 cycles of NAC; Time 4, after 6 cycles of NAC. P-values represent comparisons between groups by conducting generalized estimating equations. *P <.05 and **P <.001 represent comparisons between groups at the same time point. pCR = pathologic complete response, HER2 = human epidermal growth factor receptor-2, TNBC = triple-negative breast cancer