Skip to main content

Table 1 Clinicopathological characteristics of 15 enrolled breast tumor patients

From: Establishment and characterization of 24 breast cancer cell lines and 3 breast cancer organoids reveals molecular heterogeneity and drug response variability in malignant pleural effusion-derived models

No

SNU Name

Multiple set

Race/Ethnicity

Origin

Growth patterns

Doubling time (hours)

Morphology

Sex/Age

Tumor type

Clinical diagnosis

Histology subtype

IHC subtype

ER (+, %)

PR (+, %)

HER2 IHC

Ki-67(%)

1

SNU-2480

 

Korean (East Asian)

Pleural effusion

Adherent/Floating

17.6

Oval

F/37

Metastatic

Relapsed

IDC

TNBC

Negative

Negative

Negative

60

2

SNU-2532 A

 

Korean (East Asian)

Pleural effusion

Floating

9.9

Round

F/32

Metastatic

Relapsed

IDC

TNBC

Negative

Negative

1 + 

-

3

SNU-2924

 

Korean (East Asian)

Pleural effusion

Adherent/Floating

6

Round/Polygonal

F/46

Primary

Relapsed

IDC

TNBC

Negative

Negative

Negative

50

4

SNU-3129

 

Korean (East Asian)

Pleural effusion

Adherent

2.3

Fibroblast-like

F/53

Metastatic

Relapsed

IDC

TNBC

Negative

Negative

Negative

5

5

SNU-3171

 

Korean (East Asian)

Ascites

Adherent

8.7

Fibroblast-like/Polygonal

F/56

Metastatic

Relapsed

IDC

HR + 

Positive, 60%

Negative

2 + (FISH-)

-

6

SNU-3196

 

Korean (East Asian)

Pleural effusion

Adherent/Floating

-

Polygonal

F/70

Metastatic

Relapsed

IDC

TNBC

Focal weak

-

Negative

-

7

SNU-3223

Multiple set 1

Korean (East Asian)

Pleural effusion

Adherent

6

Polygonal

F/41

Metastatic

Relapsed

IDC

HER2 + 

Negative

Negative

3 + 

60

8

SNU-3224

Adherent

7.6

Polygonal

9

SNU-3230

Adherent/Floating

18.9

Round/Polygonal

10

SNU-3351

 

Korean (East Asian)

Pleural effusion

Adherent

19

Polygonal

F/65

Metastatic

Relapsed

ILC

HR + 

Positive, 90%

Positive, 50%

2 + (-)

-

11

SNU-3380

Multiple set 2

Pleural effusion

Adherent

8

Polygonal

F/63

Metastatic

Relapsed

IDC

HER2 + 

Negative

Negative

3 + 

-

12

SNU-3393

Adherent

76.5

Polygonal

13

SNU-3698 A

Multiple set 3

Korean (East Asian)

Pleural effusion

Adherent/Floating

8

Round

F/36

Metastatic

De Novo stage IV

IDC

HER2 + 

Negative

Negative

3 + 

-

14

SNU-3698B

Adherent/Floating

23.4

Round

15

SNU-3698 C

Floating

5.1

Round

16

SNU-3705

Adherent/Floating

5.8

Round

17

SNU-3716

Adherent/Floating

10.9

Round

18

SNU-3730

Adherent/Floating

6.7

Round

19

SNU-4842

 

Korean (East Asian)

PDX tissue

Floating

10.1

Round

F/44

Primary

Relapsed

IDC

HER2 + 

Negative

Negative

3 + 

30

20

SNU-4842-TO

     

21

SNU-4856

 

Korean (East Asian)

PDX tissue

Adherent

-

Round

F/44

Metastatic

Relapsed

IDC

HR + 

Negative

Positive, 70%

Negative

10

22

SNU-4856-TO

     

23

SNU-5126

 

Korean (East Asian)

PDX tissue

Adherent

4.7

Polygonal

F/53

Metastatic

Relapsed

IDC

HR + 

Positive, 95%

Negative

Negative

-

24

SNU-5126-TO

     

25

SNU-5188

Multiple set 4

Korean (East Asian)

Pleural effusion

Adherent

60.5

Fibroblast-like/Round

F/62

Metastatic

De Novo stage IV

IDC

HR + 

Positive, 80%

Positive, 5%

Negative

7

26

SNU-5226B

Adherent/Floating

12

Fibroblast-like/Polygonal

27

SNU-5884B

 

Korean (East Asian)

Pleural effusion

Adherent

4.3

Polygonal

F/48

Metastatic

De Novo stage IV

IDC

TNBC

Negative

Negative

Negative

-

  1. IDC Invasive Ductal Carcinoma, ILC Invasive Lobular Carcinoma, TNBC Triple Negative Breast Cancer (ER-PR-HER2-), HR +  Hormone Receptor positive (ER + and/or PR +).