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Fig. 2 | Breast Cancer Research

Fig. 2

From: Establishment and characterization of 24 breast cancer cell lines and 3 breast cancer organoids reveals molecular heterogeneity and drug response variability in malignant pleural effusion-derived models

Fig. 2

Intratumoral heterogeneity within malignant pleural effusions of breast cancer patients. A-C Clonal estimation of the multiple set 1–3. Calculated subclones and their proportions among a tumor population within the MPE are indicated with colored circles and fish plots using representative colors. The number of colored circles per each harvesting point is set to 100. The time intervals for collecting tumor cells and applied antitumor drugs are indicated below the fish plot. The VAFs of mutational clusters per multiple collected samples are indicated with a broken line graphs with representative colors. The clone numbers corresponding to the line graphs in Fig. 2 are provided on the right side of each graph, and the associated gene mutations with significantly changed VAFs are detailed in Table S4 A–4 C. The subclones of multiple set 4 could not be estimated with identical parameters and omitted from the clonal analysis. See also Table S3 A-3 C and S4 A-4 C

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Breast Cancer Research

ISSN: 1465-542X

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