Fig. 7
From: Predicting Nottingham grade in breast cancer digital pathology using a foundation model
Key Biological Processes Associated with Nottingham Grade 3 Breast Cancer. The bar chart illustrates the key biological processes associated with Nottingham Grade 3 breast cancer, identified through gene ontology (GO) analysis. The most significant processes include cell division, chromosome segregation, and the mitotic cell cycle, reflecting the rapid and aggressive proliferation characteristic of Grade 3 tumors. Other notable processes, such as mitotic spindle organization, G2/M transition of the mitotic cell cycle, and mitotic cytokinesis, further highlight the enhanced mitotic activity observed in high-grade tumors. Additionally, processes like DNA replication and regulation of cyclin-dependent kinase activity underscore the genomic instability and dysregulated cell cycle mechanisms typical of advanced breast cancer. These results provide biological insights into the distinct and aggressive nature of Nottingham Grade 3