Table 3 Association of collagen features with recurrence
Association | Collagen Feature | HR (p-value) | Invasive/in situ | Reference | |
|---|---|---|---|---|---|
Increased Risk of Recurrence | Intratumoral Collagen Quantity | HR = 4.13 (p = 0.023) | Invasive | [43] | |
Intratumoral Collagen Uniformity | HR = 3.20 (p < 0.001) | ||||
Ln F/B | HR = 3.39 (p = 0.019) | [27] | |||
Distance to Nearest 2 Fibers | HR = 1.47 (p = 0.02) | In situ | [24] | ||
Straightness | HR = 1.47 (p = 0.03) | ||||
Low COL1A1 Protein Expression | Log-rank p = 0.046 | NA | [10] | ||
Decreased Risk of Recurrence | Total Length Minus End-to-end Length (Curviness) | HR = 0.77 (p < 0.001) | In situ | [24] | |
Width (µm) | HR = 0.57 (p = 0.01) | ||||
Collagen Numbers (within the box with a specific size, 48×48 µm) | HR = 0.58 (p = 0.003) | ||||
Collagen Numbers (within the box with a specific size, 96×96 µm) | HR = 0.60 (p = 0.004) | ||||
No Significant Association | Intratumoral Collagen Organization | NS | Invasive | [43] | |
Presence of TACS-3 (%) | In situ | [50] | |||
Collagen Alignment | [50] | ||||
Total Length (µm), End-to-end Length (µm), Collagen Numbers (within the box with a specific size, 24×24 µm), Alignment of the Nearest 4 Fibers, Box Alignment 24×24 µm, Distance to Tumor/Stromal Boundary (µm), Angle Relative to Tumor/Stromal Boundary (°) | [24] | ||||
COL1A1 mRNA Expression | NA | [10] | |||