Table 10 Association of collagen features with receptor status (ER, PR, HER2)
Collagen Feature | ER Association | PR Association | HER2 Association | Invasive/In situ | Reference |
|---|---|---|---|---|---|
Ln F/B | ER− > ER+ (p < 0.001) | PR− > PR+ (p = 0.003) | NS | NA | [27] |
TACS-3 | ER− > ER+ (p = 0.002) | PR− > PR+ (p = 0.02) | HER2+ > HER2− (p = 0.002) | In situ | [50] |
Total Collagen Deposition | ER− > ER+ (p = 0.005) | NS | NS | Invasive | [44] |
Local Collagen Density | NS | PR− > PR+ (p = 0.038) | NS | ||
Local Collagen Alignment | ER− > ER+ (p = 0.031) | NS | NS | ||
TACS-3 | NS | NS | NS | ||
TACS-3 and TACS-2 | NS | NS | NS | ||
Ln F/B | NA | NS | NS | Invasive | [56] |
Collagen Solidity | ER− > ER+ (p = 0.001) | PR− > PR+ (p < 0.0001) | HER2+ > HER2− (p < 0.0001) | In situ | [22] |
Collagen Dispersion | ER+ > ER− (p = 0.019) | PR+ > PR− (p = 0.029) | NS | ||
Collagen Directionality | NS | NS | NS | ||
COL1A1 Protein Expression | ER+ > ER− (p = 0.0011) | PR+ > PR− (p < 0.0001) | NS | NA | [10] |
COL1A1 mRNA expression | ER+ > ER− (p = 0.001) | PR+ > PR− (p < 0.004) | NS | ||
Type I Collagen Protein Expression | ER+ > ER− (p < 0.01) | NA | NA | Invasive | [45] |