Fig. 4

Reversal of Vascular Endothelial Injury Markers Induced by NETs Formation in TCb Mouse Models. A Schematic representation of the mouse models used for TCb chemotherapy and CI-amidine intervention, B administration of CI-amidine to TCb mouse models reversed the elevated plasma dsDNA concentrations observed in TCb-treated mice (n = 6), C plasma levels of MPO and histone H3 in mouse models showed that CI-amidine mitigated increases induced by TCb chemotherapy, D plasma concentrations of vWF and Syndecan-4, significantly upregulated in TCb-treated mice compared to controls, were reversed by CI-amidine intervention. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001