Fig. 6

ROR1/CD3 TCE shows acceptable PK parameters in mice. (A) The schematic diagram of dosing and bleeding schedule of the PK study. (B) The format of ELISA used for detecting the blood concentration of ROR1/CD3. N = 3 mice for each time points. (C) The PK profiles of ROR1/CD3. BALB/c mouse was intravenously injected with ROR1/CD3 as mentioned in panel (A) and the serum concentration of ROR1/CD3 was detected at the indicated time points after dosing. (D) The PK parameters of ROR1/CD3 molecule in BALB/c mouse