Fig. 1
From: DNA methylation-predicted plasma protein levels and breast cancer risk
Schematic of study design. Whole blood samples were collected from Sister Study participants at enrollment when all were breast cancer-free and assayed for genome-wide DNA methylation (DNAm) profiles using either the HumanMethylation450 or MethylationEPIC BeadChips. DNAm data were used to calculate circulating concentrations of 109 plasma proteins (“Protein EpiScores”) using a pre-identified set of CpGs. Breast cancer incidence associations with Protein EpiScores were estimated using weighted Cox regression models overall and stratified by time and participant characteristics