Table 2 Associations of IGF-1 and IGFBP-3 with log-transformed expression of stem cell markers in benign breast biopsy samples (β coefficients and 95% Confidence intervals)

IGF-1, continuous log-transformed

147

0.09 (− 0.45; 0.62)

148

0.88 (− 0.30; 2.06)

141

0.03 (− 0.16; 0.21)

143

0.22 (− 0.20; 0.65)

145

0.28 (− 0.49; 1.06)

143

0.36 (− 1.12; 1.85)

IGF-1 quartiles

 Quartile 1

38

Ref

38

Ref

36

Ref

37

Ref

37

Ref

36

Ref

 Quartile 2

35

− 0.06 (− 0.46; 0.34)

36

0.69 (− 0.17; 1.55)

33

0.02 (− 0.12; 0.16)

34

0.13 (− 0.18; 0.44)

36

0.35 (− 0.23; 0.93)

36

0.33 (− 0.79; 1.46)

 Quartile 3

37

− 0.08(− 0.48; 0.32)

37

0.28 (− 0.58; 1.14)

37

− 0.02 (− 0.15; 0.12)

37

− 0.01 (− 0.32; 0.30)

36

0.20 (− 0.38; 0.78)

35

0.59 (− 0.54; 1.72)

 Quartile 4

37

− 0.03 (− 0.48; 0.41)

37

0.93 (− 0.03; 1.89)

35

0.01 (− 0.14; 0.17)

35

0.25 (− 0.10; 0.60)

36

0.56 (− 0.08; 1.20)

36

0.54 (− 0.72; 1.79)

 p-trend^a

0.59

0.36

0.66

0.57

0.45

0.25

IGFBP-3 continuous log-transformed

147

− 0.04 (− 0.94; 0.85)

148

− 0.41 (− 2.35; 1.53)

141

− 0.17 (− 0.47; 0.13)

143

− 0.60 (− 1.30; 0.10)

145

0.25 (− 1.02; 1.52)

143

0.96 (− 1.46; 3.38)

IGFBP-3 quartiles

 Quartile 1

35

Ref

36

Ref

34

Ref

36

Ref

36

Ref

36

Ref

 Quartile 2

37

− 0.11 (− 0.47; 0.26)

37

− 0.15 (− 0.93; 0.62)

35

− 0.09 (− 0.21; 0.04)

35

− 0.27 (− 0.55; 0.02)

36

− 0.19 (− 0.71; 0.33)

35

0.28 (− 0.73; 1.28)

 Quartile 3

37

0.06 (− 0.32; 0.44)

37

0.10 (− 0.72; 0.91)

34

− 0.06 (− 1.19; 0.08)

34

− 0.22 (− 0.52; 0.07)

35

0.05 (− 0.49; 0.59)

35

− 0.23 (− 1.27; 0.81)

 Quartile 4

38

− 0.12 (− 0.51; 0.27)

38

− 0.58 (− 1.42; 0.26)

38

− 0.08 (− 0.21; 0.05)

38

− 0.38 (− 0.69; − 0.08)

38

− 0.18 (− 0.73; 0.38)

37

0.11 (− 0.98; 1.20)

 p-trend^a

0.82

0.52

0.56

0.06

0.21

0.77