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Table 1 Baseline characteristics of patients based on HG

From: Pathological complete response, histologic grade, and level of stromal tumor-infiltrating lymphocytes in ER + HER2- breast cancer

Variables, N (%)

HG I/II

(N = 349)

HG III

(N = 27)

p-value

Age distribution

  

0.757

 ≤ 50

230 (65.9)

17 (63.0)

 

 > 50

119 (34.1)

10 (37.0)

 

ER expression

  

0.005

 Allred score 5–8

330 (94.6)

21 (77.8)

 

 Allred score 1–4

19 (5.4)

6 (22.2)

 

PR expression

  

0.007

 Allred score 5–8

197 (56.4)

8 (29.6)

 

 Allred score 1–4

152 (43.6)

19 (70.4)

 

Ki67 LI *

  

0.037

 ≥ 14%

39 (54.9)

7 (100)

 

 < 14%

32 (45.1)

0

 

Clinical T stage

  

0.124

 T1

39 (11.2)

1 (3.7)

 

 T2

177 (50.7)

19 (70.4)

 

 T3

133 (38.1)

7 (25.9)

 

Clinical node positivity

  

0.708

 Positive

26 (7.4)

1 (3.7)

 

 Negative

323 (92.6)

26 (96.3)

 

sTIL, mean (range)

12.9 (5–90)

38.7 (5–95)

< 0.001#

sTIL status (cutoff 10%)

  

< 0.001

 High

147 (42.1)

21 (77.8)

 

 Low

202 (57.9)

6 (22.2)

 

sTIL status (cutoff 20%)

  

< 0.001

 High

76 (21.8)

19 (70.4)

 

 Low

273 (78.2)

8 (29.6)

 

sTIL status (cutoff 30%)

  

< 0.001

 High

45 (12.9)

15 (55.6)

 

 Low

304 (87.1)

12 (44.4)

 
  1. *Patients with unavailable data were excluded
  2. #Student-t test was applied
  3. Abbreviations HG, histologic grade; ER, estrogen receptor; PR, progesterone receptor; LI, labelling index; sTIL, stromal tumor-infiltrating lymphocytes