Fig. 4

Radar chart illustrating the pathological complete response (pCR) rates based on stromal tumor-infiltrating lymphocytes (sTIL) and histologic grade (HG). The blue line represents the HG I/II group, while the red line corresponds to the HG III group, with each vertex on the hexagon indicating pCR rates according to different sTIL cutoffs. In the HG I/II group, pCR rates were statistically significantly higher in the high sTIL group compared to the low sTIL group across all cutoffs. Specifically, at a sTIL cutoff of 10%, the pCR rate was 7.5% in the high sTIL subgroup versus 2.0% in the low sTIL subgroup (p = 0.005). At a 20% cutoff, the pCR rate was 10.5% in the high sTIL subgroup compared to 2.6% in the low sTIL subgroup (p = 0.001). At the 30% cutoff, the high sTIL subgroup had a pCR rate of 13.3%, while the low sTIL subgroup had a rate of 3.0% (p = 0.001). In contrast, within the HG III group, while the high sTIL subgroup showed a trend toward higher pCR rates than the low sTIL subgroup, these differences were not statistically significant. Specifically, at a sTIL cutoff of 10%, the pCR rate was 23.8% in the high sTIL subgroup and 16.7% in the low sTIL subgroup (p > 0.999). At a 20% cutoff, the pCR rate in the high sTIL subgroup was 26.3% compared to 12.5% in the low sTIL subgroup (p = 0.633). For the 30% cutoff, the high sTIL subgroup had a pCR rate of 33.3%, while the low sTIL subgroup had a rate of 8.3% (p = 0.182)