Fig. 1

Treatment pattern of the patients. The individual therapy interventions (red: adjuvant and neoadjuvant chemotherapy; blue: radiotherapy; black: surgery; pink: maintenance therapy like endocrine therapy, antibody therapy or post- neoadjuvant chemotherapy). Green: blood samples for the BEGYN-1 study (first blood sample/baseline measurement at 0 weeks, green: blood samples after 3, 6, 9 and 12 months) over time. The basis for this is provided by the German S3 guideline. The individual treatment of the patients is shown in Figures S3 and S4