Breast Cancer Research

Table 6 Analyses of stromal protein expression analysis of RANK and RANKL across different response variables.

From: Denosumab as an immune modulator in HER2-negative early breast cancer: results of the window-of-opportunity D-BIOMARK clinical trial

	Stroma RANK- (N = 29)							Stroma RANK + (N = 27)
	Control N = 9			Experimental N = 20				Control N = 11			Experimental N = 16
	Biopsy	Surgery	p value	Biopsy	Surgery	p-value	p-inter*	Biopsy	Surgery	p value	Biopsy	Surgery	p value	p-inter*
Ki67 (%)	21.00	26.11	0.160	17.40	24.65	0.020	0.629	27.64	32.82	0.100	25.19	26.94	0.458	0.360
Cleaved caspase-3 (H-Score)	1.89	2.36	0.203	1.52	1.61	0.740	0.389	1.46	2.23	0.137	4.12	2.70	0.171	0.058
TILs (%)	11.11	15.00	0.438	6.08	10.16	0.004	0.969	4.98	11.00	0.046	8.54	17.02	0.009	0.531
sRANKL (pg/L)	0.14	0.15	0.622	0.08	0.00	0.000	0.008	0.06	0.08	0.244	0.12	0.00	0.000	0.000
OPG (pg/ml)	296.58	283.44	0.226	357.44	376.50	0.114	0.045	503.95	422.51	0.051	282.90	291.60	0.440	0.037
TRACP5b (mlU/ml)	2.22	2.42	0.662	1.43	1.84	0.398	0.739	3.60	3.80	0.744	3.07	3.04	0.815	0.713

	Stroma RANKL- (N = 37)							Stroma RANKL + (N = 18)
	Control N = 12			Experimental N = 25				Control N = 8			Experimental N = 10
	Biopsy	Surgery	p value	Biopsy	Surgery	p value	p-inter*	Biopsy	Surgery	p value	Biopsy	Surgery	p value	p-inter*
Ki67 (%)	26.58	30.83	0.204	18.84	21.84	0.140	0.739	21.75	28.25	0.036	25.50	33.30	0.123	0.807
Cleaved caspase-3 (H-Score)	1.42	1.89	0.115	2.60	1.95	0.326	0.120	2.01	2.88	0.213	3.10	2.63	0.399	0.127
TILs (%)	8.88	11.42	0.387	5.82	11.22	0.002	0.385	6.04	14.88	0.096	10.55	19.00	0.046	0.948
sRANKL (pg/L)	0.09	0.11	0.360	0.10	0.00	0.000	0.000	0.10	0.12	0.527	0.08	0.00	0.001	0.003
OPG (pg/ml)	433.69	365.64	0.070	309.12	317.85	0.365	0.049	376.05	351.36	0.213	373.50	394.68	0.182	0.068
TRACP5b (mlU/ml)	2.42	2.93	0.339	2.35	2.73	0.223	0.828	4.27	3.78	0.022	2.53	2.32	0.307	0.252

Bold indicates statistical significance, defined as p < 0.05
^*T test for non-paired samples used for comparison between the experimental and control arms

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