Breast Cancer Research

Table 5 Analysis of tumor cell protein expression of RANK and RANKL across different response variables

From: Denosumab as an immune modulator in HER2-negative early breast cancer: results of the window-of-opportunity D-BIOMARK clinical trial

	Tumor RANK- (N = 36)							Tumor RANK + (N = 19)
	Control (N = 14)			Experimental (N = 22)				Control (N = 5)			Experimental (N = 14)
	Biopsy	Surgery	p value	Biopsy	Surgery	p value	p-inter*	Biopsy	Surgery	p value	Biopsy	Surgery	p value	p-inter*
Ki67 (%)	25.71	32.00	0.041	17.95	20.68	0.147	0.292	26.20	29.40	0.384	25.43	33.50	0.062	0.359
Cleaved caspase-3 (H-Score)	1.17	2.03	0.041	1.70	1.59	0.701	0.050	3.25	3.42	0.751	4.20	2.88	0.262	0.243
TILs (%)	8.99	12.79	0.211	3.50	8.33	0.008	0.761	3.80	14.60	0.120	12.93	20.88	0.013	0.658
sRANKL (pg/L)	0.07	0.11	0.049	0.09	0.00	0.000	0.000	0.17	0.13	0.184	0.10	0.00	0.000	0.059
OPG (pg/ml)	469.14	406.96	0.063	309.41	319.89	0.351	0.039	256.39	236.59	0.184	347.73	368.44	0.091	0.034
TRACP5b (mlU/ml)	3.00	3.31	0.532	2.17	2.45	0.276	0.959	2.99	2.87	0.811	2.77	2.72	0.892	0.902

	Tumor RANKL- (N = 38)							Tumor RANKL + (N = 17)
	Control (N = 14)			Experimental (N = 24)				Control (N = 5)			Experimental (N = 12)
	Biopsy	Surgery	p value	Biopsy	Surgery	p value	p-inter*	Biopsy	Surgery	p value	Biopsy	Surgery	p value	p-inter*
Ki67 (%)	26.21	34.43	0.006	22.00	24.62	0.146	0.081	24.80	22.60	0.307	18.58	27.75	0.063	0.033
Cleaved caspase-3 (H-Score)	1.57	2.42	0.053	2.87	2.18	0.323	0.060	2.12	2.35	0.599	2.29	1.92	0.401	0.325
TILs (%)	7.91	14.21	0.082	5.92	11.94	0.002	0.941	6.80	10.60	0.330	9.67	15.75	0.048	0.615
sRANKL (pg/L)	0.08	0.09	0.396	0.10	0.00	0.000	0.000	0.16	0.18	0.605	0.08	0.00	0.001	0.046
OPG (pg/ml)	414.20	370.73	0.087	325.35	341.53	0.108	0.031	410.23	338.03	0.307	322.22	333.24	0.466	0.253
TRACP5b (mlU/ml)	2.95	3.31	0.395	2.43	2.27	0.079	0.234	3.15	2.86	0.768	2.39	3.00	0.211	0.413

Bold indicates statistical significance, defined as p < 0.05
^*T test for non-paired samples used for comparison between the experimental and control arms

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