Table 3 Expression of RANK and RANKL in tumor cells and stroma at baseline biopsy, and its relationship with treatment arm, menopausal status, surrogate molecular subtype, and histological grade
| Â | Tumor RANK | Tumor RANKL | Stroma RANK | Stroma RANKL | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tumor RANK- | Tumor RANK +  | p value | Tumor RANKL- | Tumor RANKL +  | p value | Stroma RANK- | Stroma RANK +  | p value | Stroma RANKL- | Stroma RANKL +  | p value | |
N = 36 | N = 19 | N = 38 | N = 17 | N = 29 | N = 27 | N = 37 | N = 18 | |||||
Treatment | Â | Â | 0.526 | Â | Â | 0.819 | Â | Â | 0.632 | Â | Â | 0.569 |
 Experimental | 22 (61.1%) | 14 (38.9%) | 24 (66.7%) | 12 (33.3%) | 20 (55.6%) | 16 (44.4%) | 25 (71.4%) | 10 (28.6%) | ||||
 Control | 14 (73.7%) | 5 (26.3%) | 14 (73.7%) | 5 (26.3%) | 9 (45.0%) | 11 (55.0%) | 12 (60.0%) | 8 (40.0%) | ||||
Menopausal status | Â | Â | 1,000 | Â | Â | 1,000 | Â | Â | 0.292 | Â | Â | 1,000 |
 Pre-menopausal | 16 (64.0%) | 9 (36.0%) | 17 (68.0%) | 8 (32.0%) | 11 (42.3%) | 15 (57.7%) | 17 (68.0%) | 8 (32.0%) | ||||
 Post-menopausal | 20 (66.7%) | 10 (33.3%) | 21 (70.0%) | 9 (30.0%) | 18 (60.0%) | 12 (40.0%) | 20 (66.7%) | 10 (33.3%) | ||||
Surrogate molecular subtype | Â | Â | 0.460 | Â | Â | 0.861 | Â | Â | 0.012 | Â | Â | 0.284 |
 Luminal A-like | 18 (72.0%) | 7 (28.0%) | 18 (72.0%) | 7 (28.0%) | 17 (65.4%) | 9 (34.6%) | 20 (76.9%) | 6 (23.1%) | ||||
 Luminal B-like | 13 (65.0%) | 7 (35.0%) | 14 (70.0%) | 6 (30.0%) | 5 (25.0%) | 15 (75.0%) | 12 (63.2%) | 7 (36.8%) | ||||
 TNBC | 5 (50.0%) | 5 (50.0%) | 6 (60.0%) | 4 (40.0%) | 7 (70.0%) | 3 (30.0%) | 5 (50.0%) | 5 (50.0%) | ||||
Histological grade | Â | Â | 0.137 | Â | Â | 0.308 | Â | Â | 0.215 | Â | Â | 0.422 |
 G1 | 13 (86.7%) | 2 (13.3%) | 12 (80.0%) | 3 (20.0%) | 11 (68.8%) | 5 (31.2%) | 13 (81.2%) | 3 (18.8%) | ||||
 G2 | 19 (57.6%) | 14 (42.4%) | 20 (60.6%) | 13 (39.4%) | 14 (42.4%) | 19 (57.6%) | 20 (62.5%) | 12 (37.5%) | ||||
 G3 | 4 (57.1%) | 3 (42.9%) | 6 (85.7%) | 1 (14.3%) | 4 (57.1%) | 3 (42.9%) | 4 (57.1%) | 3 (42.9%) | ||||