Table 2 Impact of denosumab on stromal tumor-infiltrating lymphocytes (TILs), subgroup analysis by surrogate molecular subtype, and menopausal status

Luminal A-like (N = 27)

Control (N = 8)

Experimental (N = 19)

p-inter*

Biopsy

Surgery

p value

Biopsy

Surgery

p value

10.04

10.25

0.958

4.61

6.23

0.144

0.738

Luminal B-like (N = 21)

Control (N = 9)

Experimental (N = 12)

p-inter*

Biopsy

Surgery

p value

Biopsy

Surgery

p value

6.50

13.11

0.070

8.55

18.04

0.012

0.527

TNBC (N = 10)

Control (N = 4)

Experimental (N = 6)

p-inter*

Biopsy

Surgery

p value

Biopsy

Surgery

p value

4.25

14.25

0.237

13.67

24.00

0.079

0.969

ER + Pre-menopausal (N = 26)

Control (N = 10)

Experimental (N = 16)

p-inter*

Biopsy

Surgery

p value

Biopsy

Surgery

p value

10.68

12.60

0.639

7.31

12.72

0.048

0.467

ER + Post-menopausal (N = 22)

Control (N = 7)

Experimental (N = 15)

p-inter*

Biopsy

Surgery

p value

Biopsy

Surgery

p value

4.57

10.57

0.062

4.87

8.75

0.041

0.511