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Table 1 Clinicopathological baseline characteristics of the 58 evaluable patients

From: Denosumab as an immune modulator in HER2-negative early breast cancer: results of the window-of-opportunity D-BIOMARK clinical trial

 

Experimental

Control

p value

Patients (n = 58)

37

21

 

Mean age (range) 56.4 (37–80)

57.0 (37–88)

55.4 (40–80)

0.14

Menopausal status

   

Pre-menopausal

17 (45.9%)

10 (47.6%)

1.0

Post-menopausal

20 (54.1%)

11 (52.4%)

Clinical stage

   

 IA

26 (70.3%)

17 (81.0%)

0.74

 IB

0 (0%)

0 (0%)

 IIA

8 (21.6%)

4 (19.0%)

 IIB

2 (5.4%)

0 (0%)

 IIIA

1 (2.70%)

0 (0%)

Histological subtype

   

 Carcinoma NOS (ductal)

21 (56.8%)

15 (71.4%)

0.31

 Invasive lobular carcinoma

12 (32.4%)

3 (14.3%)

 Others

4 (10.8%)

3 (14.3%)

Histological grade

   

 G1

13 (35.1%)

4 (19.0%)

0.43

 G2

20 (54.1%)

14 (66.7%)

 G3

4 (10.8%)

3 (14.3%)

Ki67

   

 < 15

16 (43.2%)

2 (9.5%)

0.01

 15–30

12 (32.5%)

14 (66.7%)

 > 30

9 (24.3%)

5 (23.8%)

Surrogate molecular subtype

   

 Luminal A-like

19 (51.4%)

8 (38.1%)

0.71

 Luminal B-like

12 (32.4%)

9 (42.9%)

 TNBC

6 (16.22%)

4 (19.05%)

  1. NOS, Not otherwise specified (ductal); G, Histological Grade of Nottingham; TNBC, Triple-Negative Breast Cancer