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Fig. 2 | Breast Cancer Research

Fig. 2

From: Lipid metabolic reprogramming drives triglyceride storage and variable sensitivity to FASN inhibition in endocrine-resistant breast cancer cells

Fig. 2

The lipid profile is altered in endocrine resistant breast cancer cells. a-b) Principal component analysis (PCA) plots of T47D (a) and UCD4 (b) parental (Par) and endocrine resistant cell samples (quadruplicate) profiled by mass spectrometry-based lipidomics. c-d) Venn diagrams of significantly altered lipid analytes (up- and downregulated, q < 0.05) in T47D-TamR and -FulvR (c) and UCD4-TamR, -FulvR, and -EWD cells (d) compared to Par cells. e-f) Heatmaps of the top 25 significantly altered shared lipid analytes (up- or downregulated, PLS-DA VIP supervised clustering) between, (e) T47D-TamR and -FulvR cells, and (f) UCD4-TamR, -FulvR, and -EWD cells compared to Par cells. Plots were generated using MetaboAnalyst

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Breast Cancer Research

ISSN: 1465-542X

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