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Table 2 Comparison of clinical and histological characteristics of ATM and non-ATM tumors, after quality controls

From: Breast tumors from ATM pathogenic variant carriers display a specific genome-wide DNA methylation profile

Characteristics

ATM tumors (N = 32)

Non-ATM tumors (N = 484)

ATM variant type

PV (N = 27)

VUS (N = 5)

–

Age at diagnosis

   

 Mean [range]

45.6 [28–75]‡

55.0 [41–66]

61.5 [25–82]

 SD

11.1

11.5

11.1

Year of diagnosis

   

 Mean [range]

2003 [1989–2017]&

2007 [2004–2009]

2000 [1992–2016]

 Median

2006

2007

2000

ER status

   

 Positive

23 (85.2%)¶

4 (80.0%)

350 (72.3%)

 Negative

3 (11.1%)

0 (0%)

107 (22.1%)

 Unknown

1 (3.7%)

1 (20%)

27 (5.6%)

Grade

   

 I

3 (11.1%)

1 (20%)

99 (20.5%)

 II

12 (44.4%)§

4 (80%)

186 (38.4%)

 III

9 (33.3%)§

0 (0%)

171 (35.3%)

 Unknown

3 (11.1%)

0 (0%)

28 (5.8%)

  1. ‡Significantly different from non-ATM tumors (Wilcoxon test, adjusted p-value: 1.2 × 10− 9). & Significantly different from non-ATM tumors (Wilcoxon test, adjusted p-value: 1.8 × 10− 2). ¶Proportion significantly different between ATM and non-ATM tumors (right-tailed two-proportions z-test, adjusted p-value: 0.12). §Proportion significantly different between ATM and non-ATM tumors (right-tailed two-proportions z-test, adjusted p-value: 0.21). SD: standard deviation; ER: estrogen receptors; PV: pathogenic variant; VUS: variant of uncertain clinical significance