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Fig. 3 | Breast Cancer Research

Fig. 3

From: Unveiling the key mechanisms of FOLR2+ macrophage-mediated antitumor immunity in breast cancer using integrated single-cell RNA sequencing and bulk RNA sequencing

Fig. 3

Distribution of FOLR2+ macrophages and CD8+ T cells in tumor tissue of BRCA patients. Note A Representative co-localization confocal immunofluorescence image of FOLR2+ macrophages, CD31+ blood vessels, and CD8+ T cells in primary BRCA tumor tissue (Scale bars = 50 μm); B Stratification of CD8+ T cells and FOLR2+ macrophages based on subtype using multiplex immunofluorescence quantification; C Stratification of patients based on tumor staging using multiplex immunofluorescence quantification of FOLR2+ macrophages; D Representative multiplex immunofluorescence image showing expression of CD8, FOLR2, and CD206 proteins (Scale bars = 50 μm); E Quantitative analysis of CD8+ T cell density; F Analysis of the correlation between FOLR2 expression and CD8A, CD8B expression using the TCGA-BRCA dataset (n = 1113). ***indicates P < 0.001

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Breast Cancer Research

ISSN: 1465-542X

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