Fig. 3

qHDMI images and quantitative biomarkers and trend plots in a 74-year-old patient in the non-responder group. (a, b,c) Research B-mode US and (d, e,f) qHDMI microvasculature images for their visits: (a, d) pre-chemotherapy, (b, e) mid-chemotherapy and (c, f) post-chemotherapy visits. Dashed blue and green curves are the segmented lesion boundaries before and after 2 mm dilation, respectively. Table under the images contains a selected set of qHDMI biomarkers calculated from the microvascular structure in the image. The pre-mid-post plots represent the variations of three of the biomarkers (\(\:NV\), \(\:{\tau\:}_{max}\), \(\:{MD}_{max})\) over time for this patient in the non-responder group