Table 1 Aggregated patient characteristics overall and separated into responder and non-responder categories. Clinical variables were tested for association with KI67 response using the Mann–Whitney U test and the chi-square test for continuous and categorical variables, respectively
Characteristic | Respondersa (n = 23) | Non-respondersa (n = 6) | Totala (n = 29) | p |
|---|---|---|---|---|
Age at diagnosis (years) | 62 (49–82) | 64 (59–70) | 62 (49–82) | 0.51 |
Race | Â | Â | Â | 0.19 |
Black | 2 (8.7) | 2 (33.3) | 4 (13.8) | Â |
White | 20 (87.0) | 4 (66.7) | 24 (82.8) | Â |
Unknown | 1 (4.3) | 0 (0.0) | 1 (3.4) | Â |
Ethnicity | Â | Â | Â | 1.00 |
Hispanic or Latino | 1 (4.3) | 0 (0.0) | 1 (3.4) | Â |
Non-Hispanic | 21 (91.3) | 6 (100.0) | 27 (93.1) | Â |
Unknown/Not reported | 1 (4.3) | 0 (0.0) | 1 (3.4) | Â |
Surgery | Â | Â | Â | 1.00 |
Lumpectomy | 21 (91.3) | 5 (83.3) | 26 (89.7) | Â |
Mastectomy | 2 (8.7) | 1 (16.7) | 3 (10.3) | Â |
Nuclear grade | Â | Â | Â | 0.06 |
Low (Grade 1) | 3 (13.0) | 0 (0.0) | 3 (10.3) | Â |
Intermediate (Grade 2) | 14 (60.9) | 2 (33.3) | 16 (55.2) | Â |
High (Grade 3) | 5 (21.7) | 4 (66.7) | 9 (31.0) | Â |
Indeterminate | 1 (4.3) | 0 (0.0) | 1 (3.4) | Â |
Hormone receptor status | Â | Â | Â | 0.18 |
ER and PR positive | 21 (91.3) | 4 (66.7) | 25 (86.2) | Â |
ER positive/(PR negative or PR unknown) | 2 (8.7) | 2 (33.3) | 4 (13.8) | Â |
Baseline mammographic extent of disease (mm) | 27 (5–60) | 25 (17–50) | 26 (5–60) | 0.76 |
Baseline MRI volume (cm3) | 1.590 (0.004–9.563) | 1.232 (0.437–20.123) | 1.590 (0.004–20.123) | 0.62 |