Fig. 2

Disease-free survival HR for patients with pCR and patients without pCR (reference) as a continuous function of predicted pCR probabilities using data from the primary study population. The lower the value on the y axis, the higher the impact of pCR status on the prognosis. The solid curve shows mean HR values obtained from 20,000 random sample splittings. Dashed curves show the corresponding pointwise 95% central range (2.5th and 97.5th percentiles) of the HR distribution. The gray vertical lines indicate the first, second, and third quartiles of the predicted pCR probability in the primary study population. HR, hazard ratio; pCR, pathological complete response