Fig. 2

Pre-therapeutic metabolic traits predict the hematologic toxicities caused by NACT. a Significant correlation between the lowest counts of the four cell types associated with hematological toxicity and the pre-treatment serum metabolites. (Pearson correlation; two-sided Student’s t test P < 0.05). Hb, hemoglobin; WBC, white blood cells; PLT, platelets; NEUT, neutrophils. b Pathway enrichment analyses of hematologic toxicity associated metabolites (Hypergeometric test; P < 0.05). c Four examples of metabolites and their relevance to hematological toxicity. (Pearson correlation; two-sided Student’s t test P < 0.05). Neu5Ac, N-Acetylneuraminic acid. Error bands represent 95% confidence intervals. d Multiple linear regression models constructed from different serum baseline metabolites to predict nadir cell counts and hematological toxicity during NACT. (Pearson correlation; two-sided Student’s t test P < 0.05). Error bands represent 95% confidence intervals. Supplementary Tables 3–6 provide details of the prediction models