Fig. 3
From: Oncogene activated human breast luminal progenitors contribute basally located myoepithelial cells
Profiling reveals that PIK3CAH1047R-iHBECCD117 preferentially corresponds to ductal properties. A Volcano plot showing differentially expressed genes between ductal and TDLU-located luminal cells in normal human breast tissue. Genes expressed at a higher level in ducts are indicated in blue, while red color denotes genes higher expressed in TDLUs. Thirteen lobular genes and nine ductal genes were selected based on their correlation with ML and LP states, respectively. B Bar plot showing average gene expression levels (FPKM) of ductal and lobular genes in PIK3CAH1047R-iHBECCD117 from bulk RNA-seq, showing higher expression of ductal markers. Error bars indicate standard deviation of mean. *p < 0.05, tested by two-tailed t test (n = 4)