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Table 1 Participant characteristics by cohort and case-control status (N = 8,279)

From: Plasma prolactin and postmenopausal breast cancer risk: a pooled analysis of four prospective cohort studies

 

NHS

BGS

MMHS

MCCS case-control

MCCS case-cohort

Total

Case

Control

Case

Control

Case

Control

Case

Control

Case

Subcohort

Case

Non-case

n = 1,205

n = 2,006

n = 992

n = 998

n = 257

n = 257

n = 432

n = 429

n = 555

n = 1,148

n = 3,441

n = 4,838

Age at blood draw (years)

Mean (SD)

62.8 (7)

62.5 (7)

60.8 (5)

60.8 (5)

63.1 (7)

63.1 (7)

61.7 (5)

61.2 (5)

67.2 (7)

66.9 (7)

62.8 (7)

63.1 (7)

Time between blood draw and index (years)

Mean (SD)

6.4 (4)

6.8 (5)

4.9 (3)

5.0 (3)

7.7 (4)

7.7 (4)

9.0 (6)

8.9 (6)

7.3 (4)

13.5 (3)

6.5 (5)

8.3 (5)

<10 years (%)

82.2

78.0

93.5

93.0

64.6

63.8

61.6

61.5

69.4

8.6

79.5

62.4

Fasting status at sample collection (%)

Not Reported

0

0

100

100

100

100

0

0

0

0

36.3

25.9

Fasting

69.0

70.4

0

0

0

0

72.7

73.9

88.6

88.2

47.6

56.7

Non-fasting

31.0

29.6

0

0

0

0

27.3

26.1

11.4

11.8

16.1

17.4

Weight at age 18–20 (kg)

          

Mean (SD)

57.0 (8)

57.4 (9)

57.1 (7)

56.7 (8)

59.8 (9)

59.0 (9)

54.9 (7)

54.1 (8)

55.1(8)

54.9 (7)

56.6 (8)

56.4 (8)

BMI at blood (kg/m2) (%)

<25

53.7

54.7

49.6

53.8

33.4

38.0

31.1

29.8

33.5

36.4

45.0

47.1

25–30

31.9

32.1

34.1

33.6

36.2

33.6

39.6

45.0

37.0

38.4

34.6

35.1

30+

14.4

13.2

16.3

12.6

30.4

28.4

29.3

25.2

29.6

25.2

20.4

17.8

Adult height (%)

<162.5 cm

33.5

32.8

34.3

41.6

28.6

35.8

69.7

76.0

58.6

63.9

42.0

46

162.5–172.5 cm

56.1

57.0

54.5

50.0

55.8

49.4

28.9

22.4

37.7

34.2

49.2

46.7

>172.5 cm

10.4

10.2

11.3

8.4

15.6

14.8

1.4

1.6

3.8

1.9

8.8

7.3

First-degree family history of breast cancer (%)

Yes

16.3

12.2

25.4

16.9

30.0

19.8

11.6

8.6

14.8

11.3

19.1

13.1

Standardized PRS

           

Mean (SD)

0.29 (1.0)

-0.07 (1.0)

0.41 (1.0)

0.00 (1.0)

0.39 (1.1)

-0.03 (1.0)

0.54 (0.9)

0.01 (1.0)

0.45 (1.0)

0.09 (1.0)

0.39 (1.0)

-0.01 (1.0)

% Mammographic density

Mean (SD)

20 (15)

17 (14)

20 (15)

17 (13)

20 (14)

18 (15)

18 (13)

18 (14)

20 (15)

18 (14)

20 (15)

17 (14)

Parity (%)

Nulliparous

7.8

6.5

11.6

11.6

10.9

11.4

12.5

13.1

16.9

12.4

11.2

9.8

1–2 Births

31.1

29.0

62.5

61.7

42.7

37.1

34.7

37.8

39.1

39.7

42.8

39.5

3 + Births

61.1

64.5

25.9

26.7

46.3

51.5

52.8

49.2

44.0

47.9

46.0

50.7

History of breastfeeding (%)

Ever breastfed

65.5

63.0

82.0

82.1

45.6

44.4

80.8

81.9

79.1

82.0

72.9

72.1

  1. Abbreviations: NHS, Nurses’ Health Study; BGS, Breakthrough Generations Study; MMHS, Mayo Mammography Health Study; MCCS, Melbourne Collaborative Cohort Study; SD, standard deviation; BMI, body mass index; PRS, polygenic risk score
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Breast Cancer Research

ISSN: 1465-542X

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