Quantification of intratumoral heterogeneity using habitat-based MRI radiomics to identify HER2-positive, -low and -zero breast cancers: a multicenter study

Table 3 Univariable and multivariable analyses of the training cohort to assess variables associated with odds of HER2-positive status

Variables	Univariable analysis		Multivariable analysis
Variables	OR(95%CI)	P value	OR(95%CI)	P value
Age, ≤ 40 vs>40	0.91 (0.40, 2.08)	0.82
Menopausal status, Premenopausal vs. Postmenopausal	1.66 (0.94, 2.93)	0.08
Ki-67, low vs. high	4.14 (2.16, 7.95)	< 0.001	2.93 (1.48, 5.84)	0.002
HR status, negative vs. positive	0.27 (0.15, 0.48)	< 0.001	0.40 (0.21, 0.74)	0.004
LVI, negative vs. positive	1.41 (0.80, 2.50)	0.23
Clinical T stage, T1 vs. T2 or above	1.35 (0.78, 2.32)	0.28
Clinical N stage, N0 vs. N+	0.90 (0.47, 1.73)	0.76
Histology type, IBC-NST vs. ILC or others	0.22 (0.05, 0.96)	0.04	0.34 (0.08, 1.49)	0.15
Grade, I or II vs. III	1.57 (0.91, 2.71)	0.11

Numbers in parentheses are 95% CIs. Variables emerged as significant (P < 0.05) in the univariable analyses were fed into the multivariable analysis. HER2, human epidermal growth factor receptor 2, HR, hormone receptor, LVI, lymphovascular invasion, IBC, invasive breast cancer, NST, no special type, ILC, invasive lobular carcinoma, OR, odds ratio, CI, confidence interval

ISSN: 1465-542X