Fig. 5

The evaluation and interpretation of the ITH signature for each task. The decision curves of the ITH signature for task 1 across three cohorts (a); The decision curves of the ITH signature for task 2 across three cohorts (b); The calibration curves of the ITH signature for task 1 across three cohorts (c); The calibration curves of the ITH signature for task 1 across three cohorts (d); The SHAP analyses of the ITH signatures for task 1 (e) and task 2 (f); the bar charts illustrated the weight of the top ten important features of the ITH signatures. The horizontal axis represents the average shapley values, while the vertical axis represents the habitat radiomics features; the bees-warm plots revealed the relative importance of habitat radiomics features and illustrate their actual relationships with the prediction outcomes. Each individual is represented by a single dot on each feature flow. The horizontal position of the dot is determined by the SHAP value of that feature, and dots accumulated along each feature row to show density; the heatmap plots displayed the local explanations of features. With individuals delineated along the x-axis and habitats radiomics features along the y-axis, these plots encode SHAP values using a color scale. ITH, intratumoral heterogeneity, SHAP, shapley additive explanations analysis, DCA, decision curve analysis, C, contrast-enhanced T1-weighted sequence, DWI, diffusion-weighted imaging, h, habitat