Quantification of intratumoral heterogeneity using habitat-based MRI radiomics to identify HER2-positive, -low and -zero breast cancers: a multicenter study

Chen, Haoquan; Liu, Yulu; Zhao, Jiaqi; Jia, Xiaoxuan; Chai, Fan; Peng, Yuan; Hong, Nan; Wang, Shu; Wang, Yi

doi:10.1186/s13058-024-01921-7

Fig. 4

From: Quantification of intratumoral heterogeneity using habitat-based MRI radiomics to identify HER2-positive, -low and -zero breast cancers: a multicenter study

The performance of models for each task. (a) represent AUCs of each model in the training, validation and test cohorts for task (1) (b) represent AUCs of the ITH signature in the training, validation and test cohorts for task (2) AUCs were reported with 95% CI in parentheses. (c) represent the mean ITH signature of HER2-positive tumors was higher than that of HER2-negative (all P < 0.001). (d) illustrate the mean ITH signature of HER2-low tumors was higher than that of HER2-zero (all P < 0.001). P values were calculated using the Mann-Whitney test. The horizontal lines in the boxes represent the medians, and the whiskers represent the minimum and maximum values. Circles represent outliers. ★★★ represents P<0.001. AUC, area under the receiver operating characteristic curve, CI, confidence interval, ITH, intratumoral heterogeneity, HER2, human epidermal growth factor receptor 2

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Fig. 4

Breast Cancer Research

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