Fig. 4
From: Image analysis-based identification of high risk ER-positive, HER2-negative breast cancers
Representative images for special CBCS cores located at the 1st, 10th, 90th, and 99th percentiles of the Luminal A and Luminal B DWD distribution, along with their representative patches. Each panel includes two sets of representative images: those generated from the grade-adjusted model using original images (left) and those from the grade-adjusted model of binary images (right). 1st and 10th percentile Luminal A cores and patches (upper row) exhibit dense collagenous stroma with a wavy collagen fiber pattern in original images. Conversely, 90th and 99th Luminal B cores (lower row) predominantly display high cellularity invasive carcinoma surrounded by thin collagenous stroma bands. Binarized images highlight a more irregular interface between epithelial (red) and collagenous stroma (green) regions in Luminal B tumors