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Table 1 Baseline characteristics from index pregnancy according to GDM history

From: Breast cancer in women with previous gestational diabetes: a nationwide register-based cohort study

 

GDM (n = 24,140)

No GDM (n = 683,981)

P value

Clinical characteristics

   

Age (years)

28 (25–32)

28 (25–31)

< 0.001

Primiparity

20,277 (84.0)

531,526 (77.7)

< 0.001

Pregestational BMI (kg/m2)a

27.2 (23.1–31.6)

22.8 (20.7–25.8)

< 0.001

Smoking during pregnancyb

3,832 (17.4)

102,931 (17.4)

0.841

Preexisting hypertension

594 (2.5)

8,746 (1.3)

< 0.001

Preexisting metformin treatment

674 (2.8)

5,015 (0.7)

< 0.001

Preexisting cancer (not breast)

38 (0.2)

1,142 (0.2)

0.721

Preexisting carcinoma in situ (not breast)

31 (0.1)

1,310 (0.2)

0.027

No preexisting comorbidityc

23,798 (98.6)

677,242 (99.0)

< 0.001

Demographic characteristics

   

Ethnicity

   

 Danish

19,169 (79.4)

602,906 (88.1)

< 0.001

 Immigrant, Western

625 (2.6)

21,473 (3.1)

< 0.001

 Immigrant, Non-Western

3,745 (15.5)

49,138 (7.2)

< 0.001

 Descendantd

601 (2.5)

10,464 (1.5)

< 0.001

Marital status

   

 Single/not living with a partner

2,914 (12.1)

84,200 (12.3)

0.266

 Married/living with a partner

21,226 (87.9)

599,781 (87.7)

0.266

Income, tertile

   

 Low

7,968 (33.0)

214,526 (31.4)

< 0.001

 Middle

7,694 (31.9)

234,543 (34.3)

< 0.001

 High

8,478 (35.1)

234,912 (34.3)

0.013

Highest completed education

   

 Lower secondary

5,891 (24.4)

132,315 (19.3)

< 0.001

 Upper secondary

10,064 (41.7)

287,527 (42.0)

0.283

 Post secondary

8,185 (33.9)

264,139 (38.6)

< 0.001

Occupation

   

 Employed

16,495 (68.3)

491,945 (71.9)

< 0.001

 Unemployed or on welfare payment

2,759 (11.4)

89,650 (13.1)

< 0.001

 Under education

3,160 (13.1)

68,731 (10.0)

< 0.001

 Early retirement

274 (1.1)

3,203 (0.5)

< 0.001

Obstetrical characteristics

   

Preeclampsia

1704 (7.1)

23,850 (3.5)

< 0.001

Gestational hypertension

966 (4.0)

11,019 (1.6)

< 0.001

Preterm delivery

2473 (10.2)

46,119 (6.7)

< 0.001

  1. Abbreviations: GDM, gestational diabetes mellitus; BMI, body mass index
  2. Data presented as median (interquartile range) or number (%)
  3. an = 375,932
  4. bn = 610,932
  5. c Charlson Comorbidity Index score of 0
  6. d Person born in Denmark by parents who were born outside of Denmark and without Danish citizenships