Fig. 3

A Overlapping box and jitter plots showing GSVA estimation scores of genesets related to cAMP/PKA/CREB signaling downloaded from MSigDB in luminal A ILC (red) vs luminal A NST (blue) from SCAN-B; Reactome PKA pathway = Reactome PKA mediated phosphorylation of CREB, KEGG cAMP Signaling = KEGG cAMP mediated signaling, GOBP response to cAMP = GOBP cellular response to cAMP, and GOBP regulation of cAMP = GOBP regulation of cAMP mediated signaling. B GSEA of genesets related to cAMP/PKA/CREB signaling downloaded from MSigDB in luminal A ILC vs luminal A NST from SCAN-B; Reactome PKA pathway = Reactome PKA mediated phosphorylation of CREB, KEGG cAMP Signaling = KEGG cAMP mediated signaling, GOBP response to cAMP = GOBP cellular response to cAMP, and GOBP regulation of cAMP = GOBP regulation of cAMP mediated signaling). C Disease-specific survival in luminal A ILC based on GSVA scores of GOBP regulation of cAMP signaling from METABRIC gene expression data; low expression (light-red) defined as < 50th percentile GSVA score, and high expression (red) defined as > / = 50th percentile GSVA score. D Disease-specific survival in luminal A ILC based on GSVA scores of KEGG cAMP mediated signaling from METABRIC gene expression data, low expression (light-red) defined as < 50th percentile GSVA score, and high expression (red) defined as > / = 50th percentile GSVA score. E Disease-specific survival in luminal A ILC based on GSVA scores of Cardiac β adrenergic signaling from METABRIC gene expression data, low expression (light-red) defined as < 75th percentile GSVA score, and high expression (red) defined as > / = 75th percentile GSVA score. GSVA—Gene Set Variation Analysis; MSigDB—Molecular Signatures Database; GSEA—Gene Set Enrichment Analysis; ILC—Invasive lobular breast cancer; NST—Invasive carcinoma—no special type; Lum A—Luminal A; SCAN-B—Sweden Cancerome Analysis Network—Breast; METABRIC- Molecular Taxonomy of Breast Cancer International Consortium; PKA—Protein kinase A, CREB—cAMP Response Element Binding protein; KEGG—Kyoto Encyclopedia of Genes and Genomes; GOBP—Gene Ontology Biological Process, DSS—Disease specific survival