Plasma metabolomics profiles and breast cancer risk

Breast Cancer Research

Table 3 Breast cancer risk for 12 metabolic features, nested case–control study within the New York Site of the BCFR

	m/z	RT (s)	Model 1		Model 2		Model 3
	m/z	RT (s)	OR (95% CI)	p-value	OR (95% CI)	p-value	OR (95% CI)	p-value
HILIC
1,3-Dibutyl-1-nitrosourea	101.5813	90.4	1.62 (1.13–2.32)	0.01	1.66 (1.14–2.42)	0.01	1.61 (1.04–2.51)	0.03
Sorbate	113.0597	26	0.71 (0.40–1.28)	0.26	0.72 (0.40–1.30)	0.27	0.70 (0.36–1.39)	0.31
2-Oxoglutarate	129.0182	34	0.70 (0.45–1.10)	0.13	0.70 (0.44–1.11)	0.13	0.74 (0.44–1.25)	0.26
L-Histidine	138.0662	25.4	0.45 (0.24–0.85)	0.01	0.45 (0.24–0.87)	0.02	0.31 (0.14–0.66)	0.003
N(6)-Methyllysine	161.1283	89.1	1.98 (1.13–3.46)	0.02	2.20 (1.21–4.00)	0.01	2.00 (1.01–3.98)	0.047
Glucose	181.0721	33	0.60 (0.37–0.95)	0.03	0.58 (0.36–0.92)	0.02	0.54 (0.32–0.90)	0.02
Caffeine	195.0878	31.6	0.61 (0.38–1.00)	0.049	0.61 (0.37–0.99)	0.047	0.49 (0.28–0.87)	0.01
N-Acetylgalactosamine	222.0984	27.5	0.66 (0.45–0.96)	0.03	0.65 (0.44–0.95)	0.03	0.65 (0.43–0.98)	0.04
C18
Dodecanoic acid	200.173	132.9	1.57 (0.90–2.75)	0.11	1.48 (0.85–2.57)	0.17	1.59 (0.87–2.91)	0.14
Eicosapentaenoic acid	301.2173	145.9	1.81 (0.89–3.69)	0.10	1.78 (0.84–3.75)	0.13	1.86 (0.87–3.96)	0.11
11-cis-Eicosenoic acid	346.2462	126	1.99 (1.10–3.60)	0.02	2.07 (1.12–3.81)	0.02	2.20 (1.15–4.23)	0.02
LysoPE(0:0/24:6(6Z,9Z, 12Z,15Z, 18Z, 21Z)	552.31	133.8	1.90 (1.14–3.15)	0.01	1.88 (1.11–3.16)	0.02	1.77 (1.04–3.01)	0.04

Significant metabolites features are indicated in bold
m/z mass-to-charge, RT retention time
Model 1: adjusted for age at blood (continuous). Model 2: model 1 + BOADICEA 1-year risk. Model 3: Model 2 + race and ethnicity + BMI (continuous) + alcohol (never, former and current) + smoking (never, former and current) + menopausal status

ISSN: 1465-542X