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Table 3 Associations between physical activity and mammographic breast density or BI-RADS density

From: WHO-recommended levels of physical activity in relation to mammographic breast density, mammographic tumor appearance, and mode of detection of breast cancer

 

MBD

BI-RADS

 

n (%)

ORcru (95% CI)a

ORadj (95% CI)b

n (%)

ORcru (95% CI)a

ORadj (95% CI)b

Physical activity

      

MET-hours/week

      

 Low (< 28.5)

552 (54)

1.00 (REF)

1.00 (REF)

203 (55)

1.00 (REF)

1.00 (REF)

 High (≥ 28.5)

470 (46)

1.18 (0.91–1.53)

1.05 (0.79–1.40)

164 (45)

1.08 (0.71–1.65)

1.05 (0.66–1.65)

 Continuous

1022 (100)

1.00 (1.00*-1.01)

1.00 (1.00*-1.01)

367 (100)

1.00 (1.00*-1.01)

1.00 (1.00*-1.01)

WHO guidelines

      

 Subceed

116 (11)

1.00 (REF)

1.00 (REF)

54 (15)

1.00 (REF)

1.00 (REF)

 Adhere

224 (22)

0.94 (0.58–1.55)

0.96 (0.56–1.64)

77 (21)

1.21 (0.58–2.51)

1.15 (0.52–2.50)

 Exceed

682 (67)

1.40 (0.91–2.14)

1.24 (0.78–1.98)

236 (64)

1.45 (0.78–2.69)

1.40 (0.72–2.72)

p-trend

 

0.023

0.176

 

0.215

0.269

Moderate intensity

      

 < 150 min

189 (19)

1.00 (REF)

1.00 (REF)

78 (21)

1.00 (REF)

1.00 (REF)

 150–300 min

307 (30)

1.14 (0.75–1.65)

1.18 (0.77–1.81)

111 (31)

1.19 (0.65–2.18)

1.30 (0.68–2.49)

 ≥ 300 min

513 (51)

1.40 (0.98–2.00)

1.36 (0.92–2.01)

174 (48)

1.43 (0.82–2.49)

1.43 (0.80–2.58)

p-trend

 

0.043

0.110

 

0.191

0.245

Vigorous intensity

      

 < 75 min

510 (67)

1.00 (REF)

1.00 (REF)

192 (68)

1.00 (REF)

1.00 (REF)

 75–150 min

173 (23)

1.17 (0.81–1.67)

1.20 (0.80–1.78)

65 (23)

0.93 (0.52–1.67)

1.01 (0.54–1.89)

 ≥ 150 min

78 (10)

1.42 (0.87–2.31)

1.28 (0.75–2.20)

27 (10)

1.28 (0.57–2.88)

1.25 (0.49–3.14)

p-trend

 

0.132

0.260

 

0.724

0.710

  1. Odds ratios (OR) with 95% confidence intervals (CI) predicting the odds of having a high MBD or high BI-RADS (C + D) density in relation to increasing levels of physical activity. aCrude model. bMultivariable model adjusted for: age at diagnosis, menopausal status, BMI at baseline, parity, ever oral contraceptive use, current hormone replacement therapy, and socioeconomic index
  2. MBD: mammographic breast density. BI-RADS: breast imaging-reporting and data system
  3. *Lower 95% CI ≤ 0.998. Values in bold indicate p < 0.05