Fig. 4

Aurora kinase A IHC and AURKA mRNA associates with poor survival in patients aged 40–49, and AURKA mRNA correlates with BRCAness- and DNA damage score. A–B Aurora-A and AURKA mRNA expression associated with shorter disease-specific survival in patients aged 40–49 years (n = 219 and n = 93 respectively, in-house cohort). C–D High AURKA mRNA expression was also significantly associated with shorter survival in patients aged 40–49 years in METABRIC < 50 discovery (C; n = 151) and validation (D; n = 110) cohorts. E–H Correlation between BRCAness score and DNA damage score and AURKA mRNA (E–F; in-house cohort, G–H; METABRIC < 50 discovery cohort). Scatter plots are represented with P-values by Spearman's rank correlation and the corresponding coefficients (ρ). Gene expression values are Log2-transformed mRNA levels. KM plots: numbers in brackets indicate number of patients/number of events. BRCAness- and DNA damage score calculated from Log2 transformed mRNA