Fig. 1

CAR expression in invasive breast cancer. (A) This is an example IDC case with 3 + CAR staining intensity in the membrane of the tumor cells. (B) This is an example ILC case where there is no membrane CAR in the tumor cells. Instead, it presents dot-like CAR aggregates in the cytosol of the tumor cells. The staining is all located inside the cells and not the intracellular space. (C) At a 90% positive tumor cell cutoff, there were significantly greater IDC cases with positive membrane CAR expression compared to ILC cases. *p < 0.05. (D) At a 50% positive tumor cell cutoff, there were significantly greater IDC cases with positive membrane CAR expression compared to ILC cases. **p < 0.005. (E) At a 10% positive tumor cell cutoff, there were significantly greater IDC cases with positive membrane CAR expression compared to ILC cases. ***p < 0.0005