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Fig. 4 | Breast Cancer Research

Fig. 4

From: Autophagy is required for mammary tumor recurrence by promoting dormant tumor cell survival following therapy

Fig. 4

Beclin 1 is required for mammary tumor recurrence in intact mice. (A) Primary tumor-free survival of female MTB/TAN; Beclin 1+/+(n = 38) and MTB/TAN; Beclin 1+/- mice (n = 40) administered doxycycline to induce HER2 beginning at 6 wk of age. (B) Recurrence-free survival of female MTB/TAN; Beclin 1+/+(n = 18) and MTB/TAN; Beclin 1+/- mice (n = 18) that harbored fully regressed primary tumors following doxycycline withdrawal. Median recurrence latencies are indicated

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Breast Cancer Research

ISSN: 1465-542X

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