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Fig. 3 | Breast Cancer Research

Fig. 3

From: Autophagy is required for mammary tumor recurrence by promoting dormant tumor cell survival following therapy

Fig. 3

Pharmacological or genetic inhibition of autophagy inhibits mammary tumor recurrence. (A) Schematic of orthotopic recurrence model and timing of chloroquine treatment. Recurrence-free survival of female nu/nu mice harboring MTB/TAN orthotopic primary tumors induced to regress by doxycycline withdrawal and treated with vehicle (n = 24) or 60 mg/kg/d chloroquine (n = 26), as described. (B) Schematic and recurrence-free survival of female nu/nu mice harboring fully regressed orthotopic tumors derived from vector control (n = 14), shRNA targeting Atg5 (shAtg5; n = 9), or shRNA targeting Atg7 (shAtg7; n = 11)-expressing MTB/TAN tumor cells. Median recurrence latencies are indicated

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Breast Cancer Research

ISSN: 1465-542X

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