Fig. 8

THR-70 coupled with immune signature (i20) and HER2 (THR-70Hi) captures more granular breast cancer groups compared to PAM-50. A Kaplan–Meier (KM) survival chart shows 20-year recurrence-free survival (RFS) of different patient subgroups identified by THR-70, i20, and HER2 classifier (THR70-Hi): E3 (purple), E2 (black), E1 (blue), HER2 + (yellow), PQNBC.i- (green) and PQNBC.i + (red). PNBC subtype includes breast cancers that are negative for ER, PR, HER2, AR and VDR. QNBC subtype includes breast cancers that are negative for ER, PR, HER2, ∓ AR or VDR. B KM survival chart shows 20-year RFS of different patient subgroups identified by PAM-50: Lum-A (purple), Lum-B (blue), HER2-like (yellow), basal-like (green), and claudin-low (red). C Multivariate analysis of Hazard ratios (HR) and 95% confidence interval (95% CI) for RFS by THR-70Hi and PAM-50 breast cancer groups using a Cox proportional hazards model