Table 1 HER2 status generally correlates with DCIS size, with HER2-positive DCIS often being larger than HER2-negative DCIS in most studies
References | Publication year | Total number of DCIS lesions included | Size HER2- DCIS (mm) | Size HER2 + DCIS (mm) | Reported p value (univariate analysis) |
|---|---|---|---|---|---|
Van Bockstal et al. [22] | 2014 | 89 | 30.9 ± 34.6 | 29.6 ± 23.8 | 0.544 |
Borgquist et al. [7] | 2015 | 409 | 22.8% of DCIS > 25 mm | 38.7% of DCIS > 25 mm | 0.002 |
Williams et al. [20] | 2015 | 314 | Lum A: 15.8 TN: 15.0 | HR + : 20.0 HR-: 24.5 | 0.005 |
Miligy et al. [23] | 2019 | 646 | 119 (23%) are larger than 40 mm | 47 (37%) are larger than 40 mm |  < 0.0001 |
Thorat et al. [12] | 2021 | 713 | Median size HER2 IHC 0/1 + : 13.8 mm Median size HER2 IHC 2 + : 13.5 mm | Median size: 16 mm | 0.0001 |
O’Keefe et al. [11] | 2021 | 1540 | 26% of DCIS is > 15 mm | 33% of DCIS is > 15 mm | 0.0142 |
Yang et al. [24] | 2022 | 5.628 | 72% of DCIS is < 16 mm | 64% of DCIS is < 16 mm |  < 0.001 |