Fig. 8

Summary of effects of elevated Spy1 on normal and abnormal development of the breast. Elevated Spy1 drives expansion of the MaSC population, in part by overriding p53, leading to initiation of tumours with an increase in the BCSC population. Spy1 p53 null tumours have a unique signaling signature over that of p53 null tumours which in part may contribute to increased therapeutic resistance