Fig. 2

HER3 is variably expressed across different breast cancer subtypes at diagnosis. A Relative protein expression of HER3 in patients (n = 34) diagnosed with breast tumors and classified by hormone receptor and HER2 expression subtype with B mean HER3 expression based on receptor status and C patient frequency of low and high HER3 expressing tumors D Distribution of patients based on specific hormone status E Representative immunoblots of HER3 family receptors and downstream signaling demonstrating variable HER3 involvement in these breast cancer patients F Pearson correlation analysis showing a positive correlation between HER3 expression and phosphorylation of AKT in breast cancer patients G Pearson correlation between HER3 and phosphorylation of AKT as classified by intrinsic breast cancer subtype and H representative immunohistofluorescence analysis of HER3 expressing and non HER3 expressing breast cancer biopsies